TRP Channel
TRP channels (Transient receptor potential channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC,TRPV,TRPM,TRPN, and TRPA. In group 2, there are TRPP ,and TRPML. Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRPs have been seen to have complex multidimensional roles in sensory signaling. Many TRPs function as intracellular calcium release channels.
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JNJ 17203212是可逆的竞争性的活性的 TRPV1 拮抗剂。
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Melatonin是由松果体产生的激素。
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Regorafenib (瑞格非尼; BAY 73-4506) 是多靶点抑制剂，对VEGFR1，VEGFR2，VEGFR3，PDGFRβ，Kit，RET和Raf-1的IC50分别为13 nM，4.2 nM，46 nM，22 nM，7 nM，1.5 nM和2.5 nM。
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Ibrutinib (PCI-32765)是一种有效的，高选择性的Btk抑制剂，IC50为0.5 nM，能稍许微抑制Bmx， CSK， FGR， BRK及HCK，但对EGFR， Yes， ErbB2， JAK3等作用效果稍弱。
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LFM-A13是Btk激酶选择性抑制剂，IC50值为17.2uM，也对PLK3有抑制作用。
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