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Metabolism


Metabolism is the set of life-sustaining chemical transformations within the cells of living organisms. The three main purposes of metabolism are the conversion of food/fuel to energy to run cellular processes, the conversion of food/fuel to building blocks for proteins, lipids, nucleic acids, and some carbohydrates, and the elimination of nitrogenous wastes. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments. 

  • VX-702 EY0733

    VX-702是一种高选择性p38α MAPK抑制剂，作用于p38α比作用于p38β效果高14倍。

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  • S3I-201 EY0638

    S3I-201是一种STAT3选择性抑制剂，能够抑制STAT3-DNA结合活性，IC50为20 μM，对STAT1和STAT5抑制作用弱。

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  • SB202190 EY0530

    SB202190 (FHPI)是一种有效的p38 MAPK抑制剂，靶向作用于p38α/β，IC50为50 nM/100 nM。

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  • SH-4-54 EY0512

    SH-4-54是一种有效的，未磷酸化的STAT3抑制剂， 结合STAT3蛋白（KD=300 nM）。

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  • Doramapimod EY0421

    Doramapimod (BIRB 796)是高度选择性p38α MAPK抑制剂，Kd为0.1 nM，对JNK2，c-RAF，Fyn，Lck，ERK-1，SYK，IKK2，ZAP-70，EGFR，HER2，PKA，PKC和PKCα/β/γ的抑制性较弱。

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