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Dienogest(STS-557) is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis. Dienogest is a hybrid progestin possessing characteristics both of 19-nortestosterone derivatives and progesterone derivatives.
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HMM (Hexamethylmelamine,altretamine) is a synthetic, cytotoxic, antineoplastic, s-triazine derivative that can be taken orally. It is an anti-neoplastic agent. HMM has been used to treat recurrent ovarian cancer for many years and it is well tolerated
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Artemisinin, a potent antimalarial, can be used to cure multidrug-resistant Plasmodium falciparum infections.
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Asenapine inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.
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Masitinib, a novel phenylaminothiazole-type derivative, is an inhibitor of the class III receptor tyrosine kinase stem-cell growth factor receptor (c-Kit) with IC50 of 200 nM, platelet-derived growth factor receptor α and β and the non-receptor tyrosine kinase Lyn(PDGFRα/β with IC50 of 540 nM/800 nM).
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