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Pralatrexate(Folotyn) is an inhibitor of DHFR (dihydrofolate reductase). Its IC50 is < 300 nM in some cell lines.
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Tamoxifen is a selective estrogen receptor (ER) modulator. Tamoxifen-induced apoptosis was associated with inhibition of cancerous inhibitor of protein phosphatase 2A (CIP2A) and phospho-Akt (p-Akt) in a dose-dependent manner.
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Dienogest(STS-557) is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis. Dienogest is a hybrid progestin possessing characteristics both of 19-nortestosterone derivatives and progesterone derivatives.
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HMM (Hexamethylmelamine,altretamine) is a synthetic, cytotoxic, antineoplastic, s-triazine derivative that can be taken orally. It is an anti-neoplastic agent. HMM has been used to treat recurrent ovarian cancer for many years and it is well tolerated
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Artemisinin, a potent antimalarial, can be used to cure multidrug-resistant Plasmodium falciparum infections.
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