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Other Singal pathway


  • Lenalidomide EY0006

    TNF-α inhibitor Lenalidomide (CC-5013, LEN) is an immunomodulatory drug currently approved for the treatment of multiple myeloma (MM), 5q- myelodysplasia and mantle cell lymphoma. Lenalidomide (CC-5013)是Thalidomide的衍生物，是一种TNF-α分泌抑制剂，IC50为13 nM。

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  • Lapatinib EY0007

    Lapatinib (GW572016) is a small-molecule dual inhibitor of EGFR and ErbB2 receptor kinase activities. Lapatinib可形成Lapatinib的二甲苯磺酸盐，是一种有效的EGFR和ErbB2抑制剂，IC50分别为10.2和9.8 nM。

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  • Rapamycin EY0008

    Rapamycin, an mTOR inhibitor, shows potent immunosuppressive and antiproliferative properties. Rapamycin是一种常用的选择性的mTOR抑制剂，IC50为~0.1 nM。

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  • AC0010 EY2822

    Avitinib (AC0010) a novel mutant-selective third-generation irreversible EGFR inhibitor is currently in phase I clinical trial.

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  • DAPI EY2828

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