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Ibrutinib (PCI-32765)是一种有效的，高选择性的Btk抑制剂，IC50为0.5 nM，能稍许微抑制Bmx， CSK， FGR， BRK及HCK，但对EGFR， Yes， ErbB2， JAK3等作用效果稍弱。
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TNF-α inhibitor Lenalidomide (CC-5013, LEN) is an immunomodulatory drug currently approved for the treatment of multiple myeloma (MM), 5q- myelodysplasia and mantle cell lymphoma. Lenalidomide (CC-5013)是Thalidomide的衍生物，是一种TNF-α分泌抑制剂，IC50为13 nM。
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Lapatinib (GW572016) is a small-molecule dual inhibitor of EGFR and ErbB2 receptor kinase activities. Lapatinib可形成Lapatinib的二甲苯磺酸盐，是一种有效的EGFR和ErbB2抑制剂，IC50分别为10.2和9.8 nM。
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Rapamycin, an mTOR inhibitor, shows potent immunosuppressive and antiproliferative properties. Rapamycin是一种常用的选择性的mTOR抑制剂，IC50为~0.1 nM。
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Avitinib (AC0010) a novel mutant-selective third-generation irreversible EGFR inhibitor is currently in phase I clinical trial.
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