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Other Singal pathway


  • Sorafenib EY0017

    Sorafenib (BAY 43-9006), an orally active multi-kinase inhibitor, targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. Sorafenib是Raf-1, B-Raf和VEGFR-2等的多重激酶抑制剂，IC50分别为6 nM, 22 nM和90 nM。

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  • Forskolin EY0022

    Forskolin, a powerful activator of adenylate cyclase (AC), increases cAMP levels in almost all tissues and cells. Forskolin是一种普遍存在的真核细胞腺苷酸环化酶（AC）激活剂，在细胞生理学研究中，常用来提高cAMP水平。

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  • Vismodegib EY0025

    Vismodegib (GDC-0449)是一种有效的，新型的，特异性的hedgehog抑制剂，IC50为3 nM。GDC-0449也抑制P-gp作用，IC50为3.0μM。

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  • Docetaxel EY0027

    Docetaxel, a cytotoxic antimicrotuble agent, is frequently administrated as a first line treatment for prostate cancers. Docetaxel，一种紫杉醇类似物，通过结合到稳定的微管来抑制微管解聚。

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  • SAHA EY0003

    Vorinostat (SAHA, MK0683)是一种I和II类组蛋白去乙酰化酶(HDAC)抑制剂，IC50小于86 nM。

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