MAO
MAO (L-Monoamine oxidases) are a family of enzymes that catalyze the oxidation of monoamines. In humans there are two types of MAO: MAO-A and MAO-B. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia.
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Pirlindole mesylate是MAO-A 抑制剂。
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Lazabemide hydrochloride是选择性 MAO-B 抑制剂。
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Tranylcypromine hydrochloride is a racemic mixture of (±)-Trans-2-phenylcyclopropyl-1-amine (TCP, tPCPA) · HCl that covalently inhibits the LSD and MAO enzymes. Tranylcypromine (2-PCPA) HCl是一种非选择性的不可逆的单胺氧化酶(MAO)抑制剂，用作抗抑郁药和抗焦虑药。
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Moclobemide是可逆的单胺氧化酶（MAO）抑制剂，IC50为6.1 μM，可作用于重度抑郁症。
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Safinamide Mesylate是Safinamide的甲磺酸盐，是一种选择性的且可逆的MAO-B抑制剂，IC50为98 nM，比作用于MAO-A选择性高5918倍。
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