STAT
Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that mediate many aspects of cellular immunity, proliferation, apoptosis and differentiation. They are primarily activated by membrane receptor-associated Janus kinases (JAK). Dysregulation of this pathway is frequently observed in primary tumors and leads to increased angiogenesis, enhanced survival of tumors and immunosuppression. Gene knockout studies have provided evidence that STAT proteins are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumor surveillance.
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HO-3867, an analog of curcumin, is a selective STAT3 inhibitor.
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WP1066是一种新型JAK2和STAT3抑制剂，IC50分别为2.30 μM和2.43 μM；对JAK2， STAT3， STAT5和ERK1/2具有抑制活性，但不抑制JAK1和JAK3。
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S3I-201是一种STAT3选择性抑制剂，能够抑制STAT3-DNA结合活性，IC50为20 μM，对STAT1和STAT5抑制作用弱。
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SH-4-54是一种有效的，未磷酸化的STAT3抑制剂， 结合STAT3蛋白（KD=300 nM）。
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Cryptotanshinone是一种STAT3抑制剂，抑制STAT3 Tyr705磷酸化，对STAT3 Ser727作用效果弱，对STAT1和STAT5没有作用效果。
More
-
HO-3867, an analog of curcumin, is a selective STAT3 inhibitor.
More
-
WP1066是一种新型JAK2和STAT3抑制剂，IC50分别为2.30 μM和2.43 μM；对JAK2， STAT3， STAT5和ERK1/2具有抑制活性，但不抑制JAK1和JAK3。
More
-
S3I-201是一种STAT3选择性抑制剂，能够抑制STAT3-DNA结合活性，IC50为20 μM，对STAT1和STAT5抑制作用弱。
More
-
SH-4-54是一种有效的，未磷酸化的STAT3抑制剂， 结合STAT3蛋白（KD=300 nM）。
More
-
Cryptotanshinone是一种STAT3抑制剂，抑制STAT3 Tyr705磷酸化，对STAT3 Ser727作用效果弱，对STAT1和STAT5没有作用效果。
More
