STAT
Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that mediate many aspects of cellular immunity, proliferation, apoptosis and differentiation. They are primarily activated by membrane receptor-associated Janus kinases (JAK). Dysregulation of this pathway is frequently observed in primary tumors and leads to increased angiogenesis, enhanced survival of tumors and immunosuppression. Gene knockout studies have provided evidence that STAT proteins are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumor surveillance.
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RSVA 405是AMPK 激动剂， 也是STAT3的抑制剂。
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Napabucasin是STAT3 抑制剂，也能阻断肿瘤干细胞的自主更新（self-renewal）。
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Stattic是第一个非肽类小分子，有效抑制STAT3激活和核易位，IC50为5.1 μM，高选择性作用于STAT1。
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HO-3867, an analog of curcumin, is a selective STAT3 inhibitor.
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WP1066是一种新型JAK2和STAT3抑制剂，IC50分别为2.30 μM和2.43 μM；对JAK2， STAT3， STAT5和ERK1/2具有抑制活性，但不抑制JAK1和JAK3。
More
-
RSVA 405是AMPK 激动剂， 也是STAT3的抑制剂。
More
-
Napabucasin是STAT3 抑制剂，也能阻断肿瘤干细胞的自主更新（self-renewal）。
More
-
Stattic是第一个非肽类小分子，有效抑制STAT3激活和核易位，IC50为5.1 μM，高选择性作用于STAT1。
More
-
HO-3867, an analog of curcumin, is a selective STAT3 inhibitor.
More
-
WP1066是一种新型JAK2和STAT3抑制剂，IC50分别为2.30 μM和2.43 μM；对JAK2， STAT3， STAT5和ERK1/2具有抑制活性，但不抑制JAK1和JAK3。
More
