S1P Receptor
The sphingosine-1-phosphate receptors are a class of G protein-coupled receptors that are targets of the lipid signalling molecule Sphingosine-1-phosphate (S1P). They are divided into five subtypes: S1PR1, S1PR2, S1PR3, S1PR4 and S1PR5. The sphingosine-1-phosphate receptors regulate fundamental biological processes such as cell proliferation, angiogenesis, migration, cytoskeleton organization, endothelial cell chemotaxis, immune cell trafficking and mitogenesis. Sphingosine-1-phosphate receptors are also involved in immune-modulation and directly involved in suppression of innate immune responses from T cells.
-
Fingolimod (FTY720) HCl是一种1-磷酸-神经鞘氨醇S1P受体拮抗剂，IC50为0.33 nM。
More
-
PF-543柠檬酸盐是鞘氨醇竞争性的，且可渗透入细胞的SphK1选择性抑制剂，Ki为3.6 nM，对SphK2的抑制性较弱。
More
-
SKI II是一种高度选择性的，非ATP竞争性的S1P receptor抑制剂，IC50为0.5 μM，对其他激酶，包括PI3K， PKCα和ERK2没有抑制作用。
More
