In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.
CGS 19755是活性的, 竞争性NMDA 拮抗剂。
MoreCGP 7930是GABAB 受体阳性调节剂。
MoreCGP 78608 hydrochloride是活性的, 选择性甘氨酸位点的NMDA 拮抗剂。
MoreCGP 55845 hydrochloride是活性的, 选择性 GABAB 拮抗剂。
MoreCGP 54626 hydrochloride是活性的, 选择性 GABAB 拮抗剂。
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