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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Gadolinium chloride EI1157

    Gadolinium chloride是Stretch-activated calcium的通道阻断剂， calcium-sensing的受体激动剂。

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  • Gabapentin EI1156

    Gabapentin是抗惊厥剂， Increases brain GABA。

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  • Furosemide EI1154

    Furosemide是Na+/2Cl-/K+ (NKCC) symporter 抑制剂。 也是 GABAA的拮抗剂。

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  • FTIDC EI1149

    FTIDC是mGlu1活性选择性阴性变构的调节剂（negative allosteric modulator），也是mGlu1 反向激动剂。

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  • FR 236924 EI1146

    FR 236924是选择性 PKCε 激动剂。

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