In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.
Edaglitazone是活性的,选择性 PPARγ 激动剂,抗糖尿病作用。
MoreEC 144是高亲和性,活性的选择性 Hsp90 抑制剂。
MoreEB 47是活性的 PARP-1 抑制剂。
MoreE4CPG是Group I/group II mGlu 拮抗剂。
MoreDynole 34-2是Dynamin I 抑制剂。
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