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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Furosemide EI1154

    Furosemide是Na+/2Cl-/K+ (NKCC) symporter 抑制剂。 也是 GABAA的拮抗剂。

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  • FTIDC EI1149

    FTIDC是mGlu1活性选择性阴性变构的调节剂（negative allosteric modulator），也是mGlu1 反向激动剂。

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  • FR 236924 EI1146

    FR 236924是选择性 PKCε 激动剂。

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  • FPL 55712 EI1140

    FPL 55712是Leukotriene 受体拮抗剂。

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  • FPA 124 EI1139

    FPA 124是Akt/PKB 抑制剂。

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