Home > 暂无记录 暂无记录 Signal Pathway

Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Pacritinib EY0538

    Pacritinib (SB1518)对JAK2WT，JAK2V617F，FLT3，JAK1和JAK3的IC50分别为23nM，19nM，22nM，1280nM和520nM。

    More

  • EI1 EY0546

    EI1是EZH2选择性抑制剂，对野生型EZH2和EZH2 Y641F突变型的IC50分别为15 nM和13 nM。

    More

  • Ozagrel EY0532

    Ozagrel是高选择性的血栓素a2（TXA2）合成酶抑制剂。

    More

  • Adefovir Dipivoxil EY0534

    Adefovir Dipivoxil可阻断HBV逆转录酶。

    More

  • Talazoparib EY0535

    BMN 673是一种新型的PARP抑制剂，IC50为0.58 nM，也有效抑制PARP-2，但不抑制PARG，对PTEN突变型高度敏感。

    More
    • Current page348, Total Pages360, Total Record1798 First Prev 346347348349350 Next Last Goto
More