In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.
Ritonavir是一种HIV蛋白酶抑制剂,用于治疗HIV感染和AIDS。
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MoreAZD2932是VEGFR-2和PDGFR的有效抑制剂,对PDGFRβ)、VEGFR-2和Flt-3的IC50值分别为4 nM、8 nM和7 nM。
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