In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.
(-)-MK 801马来酸盐是(+)-MK-801的对映体,(+)-MK-801是高效选择性NMDA受体拮抗剂。
MoreCobimetinib是MEK1/2高选择性抑制剂。
MoreMycophenolate Mofetil是一种非竞争性的,选择性的,可逆的inosine monophosphate dehydrogenase I/II(次黄嘌呤核苷磷酸脱氢酶I/II)抑制剂, IC50分别为39 nM和27 nM。
MorePrednisone是皮质类固醇试剂,有免疫抑制作用。
MoreNicorandil 钾离子通道活化剂。
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