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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

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    GSK429286A是ROCK1和ROCK2的选择性抑制剂，IC50分别为14 nM和63 nM。

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  • Didanosine EY0431

    Didanosine (去羟肌苷; Videx) 是逆转录酶抑制剂，IC50为490nM。

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    Dapagliflozin是口服活性的SGLT2抑制剂，可作用于2型糖尿病。

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  • Clinofibrate EY0422

    Clinofibrate抑制hydroxymethylglutaryl coenzyme A reductase (HMGCR)（羟甲基戊二酰辅酶A还原酶），IC50为0.47 mM，是一种降脂剂，用于控制血液中的高胆固醇和甘油三酯水平。

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  • Santacruzamate A EY0424

    Santacruzamate A 是一类天然产物，是一种高效的具有选择性的组蛋白去乙酰化酶的抑制剂。

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