In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.
Baicalin is a known prolyl endopeptidase inhibitor that induces apoptosis in pancreatic cancer cells.
MoreXL019是JAK2选择性抑制剂,IC50为2.2 nM,比对JAK1的抑制性高100倍,有很好的分子生物学和细胞活性。
MorePolydatin, 3,4’,5-trihydroxystilbene-3-β-mono-D-glucoside, 是从多年生草本Polygonum Cuspidatum Sieb.et Zucc的根茎提取的一种结晶组分。
More槲皮素是一具抗癌活性的类黄酮。
MoreADL5859是δ-阿片受体选择性激动剂,Ki为0.8 nM,对hERG有弱抑制性。
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