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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • AVL-292 EY0930

    AVL-292是共价结合的，高选择性口服活性Btk抑制剂，IC50为0.5 nM，比对其它激酶的抑制性高1400倍以上。

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  • A922500 EY0934

    A922500是人类和小鼠DGAT-1抑制剂，IC50分别为7 nM和24 nM，比作用于相关的酰基转移酶，hERG及抗靶面板的选择性高。

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  • Desonide EY0913

    Desonide是非氟化皮质类固醇抗炎剂，能作用于糖皮质激素受体。

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  • LY2090314 EY0916

    LY2090314是高活性GSK-3抑制剂，对GSK-3α和GSK-3β的IC50分别为1.5 nM和0.9 nM。可提高以铂类为基础的化疗方案的疗效。

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  • KU-0060648 EY0920

    KU-0060648是DNA-PK和PI3Kα/β/δ双重抑制剂，IC50分别为8.6 nM和4 nM/0.5 nM/0.1 nM，对PI3Kγ抑制作用稍弱，IC50为0.59 μM。

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