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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

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    LY2784544是一种有效的JAK2抑制剂，IC50为3 nM，作用于JAK2V617F有效，比作用于JAK1和JAK3选择性高8和20倍。

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  • Desloratadine EY1100

    Desloratadine是一种有效的人组胺H1受体拮抗剂，IC50为51nM.

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  • D 4476 EY1079

    D 4476 是一种有效的，选择性的，细胞渗透性 CK1 (casein kinase 1) 抑制剂，无细胞测定中对来自粟酒裂殖酵母的 CK1 和 CK1δ，IC50 分别为 200 nM 和 300 nM 。也是一种 ALK5 抑制剂，IC50 为 500 nM。

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  • NSC 405020 EY1084

    NSC-405020是MT1-MMP抑制剂，能特异地靶向MT1-MMP的PEX结构域，不会抑制MT1-MMP和MMP-2的催化活性。

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  • A-966492 EY1085

    A-966492是一种新型有效的PARP1和PARP2抑制剂，Ki分别为1 nM和1.5 nM。

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