Home > 暂无记录 暂无记录 Signal Pathway

Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Rosuvastatin Calcium EY1293

    Rosuvastatin Calcium是一种竞争性HMG-CoA还原酶抑制剂， with IC50为11 nM。

    More

  • Indoximod EY1295

    Indoximod是一种IDO抑制剂, 并逆转IDO介导的免疫抑制。

    More

  • Fluconazole EY1300

    Fluconazole是抗真菌化合物，可用于表面和全身性的真菌感染。

    More

  • Droxinostat EY1281

    Droxinostat是一种选择性的HDAC抑制剂，最有效作用于HDACs 6和8，IC50为2.47μM和1.46 μM，比作用于HDAC3选择性高8倍，对HDAC1， 2， 4， 5， 7， 9，和10没有抑制作用。

    More

  • PF-477736 EY1284

    PF-477736是一种有效的，选择性，ATP竞争性Chk1抑制剂，Ki为0.49 nM，也抑制VEGFR2， Aurora-A， FGFR3， Flt3， Fms (CSF1R)， Ret和Yes。作用于Chk1比作用于Chk2选择性高100倍左右。

    More
    • Current page319, Total Pages360, Total Record1798 First Prev 317318319320321 Next Last Goto
More