In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.
FTI-277盐酸盐是法尼基转移酶FTase抑制剂,高效Ras CAAX肽模拟物,可抑制H-Ras和K-Ras信号转导。
MoreAT9283是一种有效的JAK2/3抑制剂,IC50为1.2 nM/1.1 nM;对Aurora A/B, Abl(T315I)也有效。
MoreAtropine sulfate monohydrate是毒蕈碱乙酰胆碱受体拮抗剂。
MoreRosuvastatin Calcium是一种竞争性HMG-CoA还原酶抑制剂, with IC50为11 nM。
MoreIndoximod是一种IDO抑制剂, 并逆转IDO介导的免疫抑制。
More
