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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

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    Resminostat是HDAC1/3/6抑制剂，IC50为43到72 nM，而对HDAC8的IC50为877 nM。

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  • NMS-P937 EY1202

    NMS-1286937是选择性的口服生物相容性PLK1抑制剂，IC50为2 nM，具有抗肿瘤活性，对PLK2和PLK3无活性。

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  • Nexturastat A EY1210

    Nexturastat A是HDAC6高度选择性抑制剂，IC50为5 nM，对其它HDAC亚型无抑制性。

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  • Miltefosine EY1191

    Miltefosine作用于癌细胞系A431和HeLa，抑制PI3K/Akt活性，ED50分别为17.2 μM和8.1 μM，是第一个用于治疗内脏利什曼病的口服药物，有效对抗前鞭毛体和无鞭毛体。

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  • Dipyridamole EY1197

    Dipyridamole是磷酸二酯酶抑制剂，能阻断红细胞和血管内皮细胞对腺苷的吸收和代谢。

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