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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

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    Droxinostat是一种选择性的HDAC抑制剂，最有效作用于HDACs 6和8，IC50为2.47μM和1.46 μM，比作用于HDAC3选择性高8倍，对HDAC1， 2， 4， 5， 7， 9，和10没有抑制作用。

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    PF-477736是一种有效的，选择性，ATP竞争性Chk1抑制剂，Ki为0.49 nM，也抑制VEGFR2， Aurora-A， FGFR3， Flt3， Fms (CSF1R)， Ret和Yes。作用于Chk1比作用于Chk2选择性高100倍左右。

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    Glycyrrhizic acid is a widely used anti-inflammatory agent isolated from the licorice root.

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  • Prasugrel EY1266

    Prasugrel是ADP受体抑制剂，能通过不可逆的与P2Y12受体结合降低血小板的聚集。

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  • Cerdulatinib EY1267

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