In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.
Repaglinide是氨基甲酰甲基苯甲酸(CMBA)衍生物,可作用于II型糖尿病。
MoreIEM 1754 dihydrobroMide是一种选择性AMPA/kainate受体抑制剂,作用于GluR1和GluR3,IC50为6 μM。
MoreAmprenavir (Agenerase)是HIV蛋白酶抑制剂,Ki为0.6 nM。
MoreMianserin盐酸盐是H1受体反向激动剂,有抗抑郁活性。
MorePU-H71是Hsp90抑制剂,IC50为50 nM。
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