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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • AT7867 EY0267

    AT7867是一种有效的，ATP竞争性的Akt1/2/3和p70S6K/PKA抑制剂，IC50分别为32 nM/17 n/47 nM和85 nM/20 nM，对AGC激酶家族以外几乎没有抑制活性。

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  • Pravastatin sodium EY0269

    Pravastatin sodium, a hydrophilic inhibitor, inhibits HMG-CoA reductase resulting in the reduction of cholesterol synthesis. Pravastatin sodium是HMG-CoA还原酶抑制剂，对甾醇合成的IC50为5.6 μM。

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  • TAK-875 EY0273

    TAK-875是一种选择性GPR40激动剂，EC50为14 nM，比油酸有效400倍。

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  • Atorvastatin Calcium EY0274

    Atorvastatin calcium, a hydrophilic inhibitor, inhibits the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Atorvastatin hemicalcium salt 是高活性HMG-CoA还原酶抑制剂，IC50为8 nM。

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  • Go6976 EY0278

    Go6976 is a potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM), selectively inhibits PKCα, and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively).

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