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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Honokiol EY0371

    Honokiol, a low molecular weight natural product isolated from the bark of magnolia officinalis, possesses potent anticancer activities which is chiefly via the inhibition of AKT and mitogen-activated protein kinase (MAPK) phosphorylation. Honokiol是木兰的有效成分，抑制Akt磷酸化，且促进ERK1/2磷酸化。

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  • AGI-6780 EY0372

    AGI-6780, a heterocyclic urea sulfonamide molecule, potently and selectively inhibits the tumor-associated IDH2 R140Q mutant. AGI-6780 是一种强效的选择性 IDH2 R140Q mutant抑制剂，其IC50为 23 nM。

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  • MG-101 EY0341

    MG-101是一种有效的半胱氨酸蛋白酶抑制剂, 作用于钙蛋白酶I, 钙蛋白酶II, 组织蛋白酶B, 和组织蛋白酶L, Ki值分别为190 nM , 220 nM, 150 nM, 500 pM.

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  • Cryptotanshinone EY0355

    Cryptotanshinone是一种STAT3抑制剂，抑制STAT3 Tyr705磷酸化，对STAT3 Ser727作用效果弱，对STAT1和STAT5没有作用效果。

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  • GSK343 EY0356

    GSK343是一种选择性EZH2抑制剂，IC50为4 nM，比作用于EZH1选择性高60倍，比作用于其他组蛋白甲基转移酶选择性高1000倍以上。

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