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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • FR 180204 EY0292

    FR 180204 是一种ATP-竞争性的选择性的ERK抑制剂，其作用于ERK1 和 ERK2的Ki分别为0.31 μM 和 0.14 μM。

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  • PF-4708671 EY0297

    PF-4708671是一种可渗透细胞的p70 S6K1亚型抑制剂，Ki/IC50为20 nM/160 nM，作用于S6K1比作用于S6K2选择性高400倍，作用于S6K1比作用于MSK1和RSK1/2选择性分别高4和20倍以上，是第一个报道的S6K1特异性抑制剂。

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  • RO4929097 EY0299

    RO4929097是一种γ secretase抑制剂，IC50为4 nM，抑制Aβ40和Notch的细胞加工，EC50分别为14 nM和5 nM。

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  • AT7867 EY0267

    AT7867是一种有效的，ATP竞争性的Akt1/2/3和p70S6K/PKA抑制剂，IC50分别为32 nM/17 n/47 nM和85 nM/20 nM，对AGC激酶家族以外几乎没有抑制活性。

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  • Pravastatin sodium EY0269

    Pravastatin sodium, a hydrophilic inhibitor, inhibits HMG-CoA reductase resulting in the reduction of cholesterol synthesis. Pravastatin sodium是HMG-CoA还原酶抑制剂，对甾醇合成的IC50为5.6 μM。

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