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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

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    Simvastatin (Zocor)是HMG-CoA还原酶的竞争性抑制剂，Ki为0.1-0.2 nM。

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    Aloxistatin 是一种不可逆的膜透过性cysteine protease 抑制剂。

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  • Crenolanib EY0473

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