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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • TTNPB EY0475

    TTNPB 是RAR激动剂，对人RARα，β和γ的IC50分别为5.1 nM，4.5 nM和9.3 nM。

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  • SB505124 EY0501

    SB505124是TGFβ受体ALK4和ALK5抑制剂，IC50分别为129 nM和47 nM，还能抑制ALK7，但对ALK1，2，3和6无抑制性。

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  • Simvastatin EY0506

    Simvastatin (Zocor)是HMG-CoA还原酶的竞争性抑制剂，Ki为0.1-0.2 nM。

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  • Aloxistatin EY0471

    Aloxistatin 是一种不可逆的膜透过性cysteine protease 抑制剂。

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  • SP2509 EY0472

    SP2509是组蛋白去甲基化酶LSD1新型抑制剂，IC50值为13nM，对MAO-A和MAO-B基本无抑制作用。

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