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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • SH-4-54 EY0512

    SH-4-54是一种有效的，未磷酸化的STAT3抑制剂， 结合STAT3蛋白（KD=300 nM）。

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  • Sirtinol EY0524

    Sirtinol是一种特异性SIRT1和SIRT2抑制剂，IC50分别为131 μM和38 μM。

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  • Tenovin-1 EY0525

    Tenovin-1是SIRT1和SIRT2抑制剂，及p21和p53活化剂。

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  • Tideglusib EY0527

    Tideglusib是不可逆的非ATP竞争性GSK-3β抑制剂，IC50为60 nM。

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  • TTNPB EY0475

    TTNPB 是RAR激动剂，对人RARα，β和γ的IC50分别为5.1 nM，4.5 nM和9.3 nM。

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