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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

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    Panobinostat (LBH589)是一种新型的，广谱的HDAC抑制剂，IC50为5 nM。

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  • BIX 02188 EY0802

    BIX 02188是一种选择性的MEK5抑制剂，IC50为4.3 nM，也抑制ERK5催化活性，IC50为810 nM，且不抑制与其密切相关的激酶MEK1， MEK2， ERK2，和JNK2。

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  • RGFP966 EY0806

    RGFP966是一种HDAC抑制剂，作用于HDAC3的IC50为0.08μM ，比作用于其他HDAC选择性高200倍以上。

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  • QNZ EY0813

    QNZ (EVP4593)有效抑制NF-κB激活和TNF-α产生，IC50分别为11 nM和7 nM。

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  • AT13148 EY0783

    AT13148是口服的多AGC激酶抑制剂，有很好的抗肿瘤活性，是AKT，p70S6K，PKA，ROCK和SGK抑制剂。

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