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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

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    Y-27632 2HCl是一种选择性的ROCK1(p160ROCK)抑制剂，Ki为140 nM，比对其他激酶包括PKC，cAMP依赖性蛋白激酶， MLCK和PAK的作用强200多倍。

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  • WZ4002 EY0768

    WZ4002是EGFR突变选择性抑制剂，对EGFR(L858R)和(T790M)的IC50分别为2 nM和8 nM，对ERBB2磷酸化(T798I)无抑制性。

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  • PJ34 HCl EY0779

    PJ34 HCl 是PJ34的盐酸盐形式，是一种PARP抑制剂，EC50为20 nM，同等有效作用于PARP1/2。

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