Home > 暂无记录 暂无记录 Signal Pathway

Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Pinometostat EY0837

    EPZ5676是蛋白甲基转移酶DOT1L的S-腺苷甲硫氨酸(SAM)竞争性抑制剂，Ki为80 pM，比作用于所有其他PMTs选择性高37，000以上，抑制肿瘤H3K79甲基化。

    More

  • PCI-34051 EY0840

    PCI-34051是高活性的HDAC8特异性抑制剂，IC50为10 nM，比对其它HDAC亚型的抑制性高200倍以上。

    More

  • PYR-41 EY0844

    PYR-41是特异的可渗透入细胞的泛素激活酶E1抑制剂，IC50< 10 uM，对E2几乎无活性。

    More

  • PD98059 EY0820

    PD98059是一种非ATP竞争性的MEK抑制剂，IC50为2 μM，特异性抑制MEK-1介导的MAPK激活；不直接抑制ERK1或ERK2。

    More

  • Panobinostat EY0821

    Panobinostat (LBH589)是一种新型的，广谱的HDAC抑制剂，IC50为5 nM。

    More
    • Current page264, Total Pages352, Total Record1760 First Prev 262263264265266 Next Last Goto
More