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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

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    U0126-EtOH(U-0126)是MEK1和2选择性抑制剂，IC50分别为70nM和60nM，对ΔN3-S218E/S222D MEK的亲和力比PD098059强100倍。

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  • Caffeic Acid Phenethyl Ester EY1129

    Caffeic acid phenethyl ester是一种强效的特异性NF-κB活化抑制剂，也能够表现出抗氧化、免疫调节和抗炎活性。

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  • PD184352 EY1139

    PD184352 (CI-1040)是一种ATP非竞争性的MEK1/2抑制剂，IC50为17 nM，对MEK1/2的选择性比MEK5高100倍。

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  • EHT 1864 EY1147

    EHT 1864是Rac1信号转导抑制剂，能调节γ-分泌酶介导的APP。

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  • Elaiophylin EY1094

    Elaiophylin大环内脂类抗菌素，作用于恶性疟原虫K1a 和布氏布锥虫GUTat 3.1 品系，具有抗原生动物活性，IC50分别为370 ng/mL和460 ng/mL。

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