Home > 暂无记录 暂无记录 Signal Pathway

Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • EPZ004777 EY0882

    EPZ004777是高活性DOT1L抑制剂，IC50为0.4 nM。

    More

  • TRAM-34 EY0884

    TRAM-34是中电导的钙激活的钾离子通道（KCa3.1），Kd为20 nM，不抑制细胞色素P450。

    More

  • Nintedanib EY0907

    Nintedanib (BIBF 1120)是三重血管激酶抑制剂，对VEGFR1/2/3，FGFR1/2/3和PDGFRα/β的IC50分别为34 nM/13 nM/13 nM，69 nM/37 nM/108 nM和59NM。

    More

  • Sodium butyrate EY0878

    Sodium Butyrate (丁酸钠) 被报道证实为HDAC抑制剂，从而导致组蛋白过乙酰化。

    More

  • AZD4547 EY0881

    AZD4547是一种新型选择性的FGFR抑制剂，靶向作用于FGFR1/2/3，IC50为0.2 nM/2.5 nM/1.8 nM，对FGFR4， VEGFR2(KDR)具有微弱的作用活性，但对IGFR， CDK2和p38几乎没有作用活性。

    More
    • Current page262, Total Pages352, Total Record1759 First Prev 260261262263264 Next Last Goto
More