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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • SC75741 EY1181

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  • KN-62 EY1183

    KN-62 is a selective, cell permeable inhibitor of calcium/calmodulin-dependent kinase II (CaMKII; IC50 = 900 nM).

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  • 1-Azakenpaullone EY1188

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  • MK-801 EY1192

    MK-801 (Dizocilpine)是一种有效的N-methyl-D-aspartate(NMDA)受体拮抗剂，Ki为30.5 nM。

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  • AZD1208 EY1200

    AZD1208是口服活性的PIM高选择性抑制剂，对Pim1, Pim2, 和 Pim3的IC50分别为5 nM, 25 nM 和 16 nM。

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