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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Valproic acid sodium salt EY1327

    Valproic acid sodium salt (Sodium valproate)是一种HDAC抑制剂，IC50为0.4 mM，也抑制GABA-转氨酶或琥珀酸半醛脱氢酶。

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  • Losmapimod EY1329

    Losmapimod一种是口服活性的p38 MAPK抑制剂，对p38α和p38β的pKi为8.1和7.6。

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  • CHIR-124 EY1333

    CHIR-124是高活性的Chk1抑制剂，IC50为0.3 nM，比对Chk2，CDK2/4和Cdc2的抑制性高2000倍，500倍和5000倍。

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  • Ki16425 EY1291

    Ki16425是竞争性的可逆的LPA拮抗剂，对LPA1，LPA2和LPA3的Ki分别为0.34 μM，6.5 μM和0.93 μM，而对LPA4，LPA5和LPA6无活性。

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  • Mdivi-1 EY1292

    Mdivi-1是一个具有选择性和细胞穿膜性的线粒体分裂抑制剂，抑制DRP1（发动蛋白相关GTP酶）和Dynamin I (Dnm1)的IC50为1-10 μM。

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