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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • (+)-Bicuculline EY1411

    (+)-Bicuculline是一种竞争性GABAA受体拮抗剂，IC50为2 μM，也抑制Ca(2+)激活的钾离子通道。

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  • Baicalein EY1417

    Baicalein是CYP2C9和脯氨酰肽链内切酶抑制剂。

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  • U-104 EY1420

    U-104是一种有效的碳酸酐酶(CA)抑制剂，作用于CA IX和CA XII，Ki分别为45.1 nM和4.5 nM，对CA I和CA II抑制活性弱。

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  • Pemetrexed EY1421

    Pemetrexed是一种新型抗叶酸抗代谢药物，作用于TS， DHFR和GARFT时，Ki分别为1.3 nM，7.2 nM，和65 nM。

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  • SB415286 EY1394

    SB 415286是可渗透入细胞的ATP竞争性GSK3α选择性抑制剂，IC50和Ki分别为78 nM和31nM。

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