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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • OG-L002 EY1384

    OG-L002是一种有效的，特异性的LSD1抑制剂，IC50为20 nM，比作用于MAO-B和MAO-A选择性分别高36和69倍。

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  • Fedratinib EY1393

    TG-101348 (SAR302503)是JAK2选择性抑制剂，IC50为3 nM，作用于JAK2比作用于JAK1和JAK3选择性高35和334倍，同时还能抑制BRD4，IC50为340 nM。

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  • NLG919 EY1350

    NLG919是一种新型有效的indoleamine-2，3-dioxygenase (IDO)（吲哚胺-2，3-双加氧酶）抑制剂，EC50为75 nM。

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  • BGJ398 EY1367

    BGJ398 (NVP-BGJ398)是一种选择性的FGFR抑制剂，作用于FGFR1/2/3，IC50为0.9 nM/1.4 nM/1 nM，作用于FGFR比作用于FGFR4和VEGFR2选择性高40倍以上，对Abl， Fyn， Kit， Lck， Lyn和Yes几乎没有抑制活性。

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  • Valproic acid sodium salt EY1327

    Valproic acid sodium salt (Sodium valproate)是一种HDAC抑制剂，IC50为0.4 mM，也抑制GABA-转氨酶或琥珀酸半醛脱氢酶。

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