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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • U-104 EY1420

    U-104是一种有效的碳酸酐酶(CA)抑制剂，作用于CA IX和CA XII，Ki分别为45.1 nM和4.5 nM，对CA I和CA II抑制活性弱。

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  • Pemetrexed EY1421

    Pemetrexed是一种新型抗叶酸抗代谢药物，作用于TS， DHFR和GARFT时，Ki分别为1.3 nM，7.2 nM，和65 nM。

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  • SB415286 EY1394

    SB 415286是可渗透入细胞的ATP竞争性GSK3α选择性抑制剂，IC50和Ki分别为78 nM和31nM。

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  • AZD7762 EY1398

    AZD7762是Chk1的抑制剂，IC50为5 nM，对Chk2的抑制性与Chk1相近，但对CAM，Yes，Fyn，Lyn，Hck和Lck的抑制性较弱。

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  • H 89 2HCl EY1400

    H 89 2HCl是一种有效的PKA抑制剂，Ki为48 nM，作用于PKA比作用于PKG选择性高10倍，比作用于PKC， MLCK，钙调蛋白激酶II和酪蛋白激I/II选择性高500倍。

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