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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

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    PJ34是一种PARP抑制剂，EC50为20 nM，同等效果作用于PARP1/2。

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  • AR-A014418 EY1572

    AR-A014418是GSK3β选择性抑制剂，IC50为104 nM，对其它26种激酶无明显抑制性。

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  • SMI-4a EY1575

    SMI-4a是ATP竞争性Pim激酶抑制剂，对Pim-1和Pim-2的IC50分别为21nM和100nM，对其它50种激酶几乎无活性。

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  • Naltrexone HCl EY1576

    Naltrexone Hydrochloride (盐酸纳曲酮) 是阿片受体拮抗剂。

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  • Hygromycin B EY1543

    Hygromycin B是抗生素，对大多数细菌、真菌和一些真核生物有效。

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