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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • L-838，417 EI1501

    L-838，417是具有亚型选择性的 GABAA 部分激动剂。

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  • L-693，403 maleate EI1484

    L-693，403 maleate是高亲和性 σ 的配体。

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  • L-701，252 EI1486

    L-701，252是NMDA 拮抗剂， 作用于甘氨酸位点 （glycine site）。

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  • L-701，324 EI1487

    L-701，324是NMDA 拮抗剂， 作用于甘氨酸位点 （glycine site）。

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  • L-655，240 EI1477

    L-655，240是活性的， 选择性 thromboxane A2/prostaglandin endoperoxide 拮抗剂。

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