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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

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    L-685，458是活性选择性的 γ-secretase 抑制剂。

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    L-165，041是活性的 PPARδ 激动剂。

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    L-168，049是活性的， 口服活性保留的人 glucagon 受体拮抗剂。

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    L-364，373是KV7.1 离子通道激动剂激活IKs。

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    L 006235是活性的 cathepsin K 抑制剂。

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