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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • NS 11021 EI1938

    NS 11021是BKCa (KCa1.1) 通道的激动剂。

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  • NS 19504 EI1940

    NS 19504是BKCa (KCa1.1) 通道的激动剂。

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  • NS 309 EI1942

    NS 309是KCa2，KCa3.1 通道阳性变构的调节剂（positive allosteric modulator。

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  • NS 3623 EI1943

    NS 3623是KV11.1 (hERG) 通道激动剂， 抗心律失常的活性。。

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  • NPS 2143 hydrochloride EI1933

    NPS 2143 hydrochloride是calcium-sensing受体选择性拮抗剂， 口服有效的催化剂。

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