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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Org 20599 EI2021

    Org 20599是阳性变构的调节剂（positive allosteric modulator）且是GABAA 受体的直接激动剂。

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  • Oncrasin 1 EI2008

    Oncrasin 1是Oncrasin 1 induces abnormal nuclear aggregation of PKCι， proapoptotic。

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  • ONO 4817 EI2010

    ONO 4817是Broad spectrum MMP 抑制剂。

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  • ONO 6818 EI2011

    ONO 6818是高亲和性，选择性 人 neutraphil elastase 1 (HNE1) 抑制剂， 口服 active。

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  • ONO 8130 EI2012

    ONO 8130是EP1 受体 拮抗剂。

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