In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.
NPS 2143 hydrochloride是calcium-sensing受体选择性拮抗剂, 口服有效的催化剂。
MoreNPS 2390是Group I mGlu 拮抗剂。
MoreNQTrp是Aβ 低聚物(oligomer)活性抑制剂,能抑制原纤维形成(fibril formation)。
Morenor-Binaltorphimine dihydrochloride是经典的 κ 选择性 拮抗剂。
MoreNorketamine hydrochloride是活性的, 非竞争性 NMDA 拮抗剂。
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