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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

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    PF 6274484是高亲和性，活性的 covalent EGFR 激酶抑制剂。

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  • PF 670462 EI2136

    PF 670462是活性的，选择性 CK1ε and CK1δ 抑制剂。

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  • PF 06465469 EI2123

    PF 06465469是活性的 ITK 抑制剂， 也是抑制 BTK。

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  • PF 3845 EI2127

    PF 3845是选择性 FAAH 抑制剂。

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  • PETCM EI2115

    PETCM是Caspase-3的激动剂。

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