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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Rottlerin EI2380

    Rottlerin是有报道的PKCδ抑制剂。

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  • Ro 51 EI2364

    Ro 51是活性的 P2X3， P2X2/3 拮抗剂。

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  • Ro 64-5229 EI2368

    Ro 64-5229是选择性非竞争性mGlu2拮抗剂。

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  • Ro 67-4853 EI2369

    Ro 67-4853是group I mGlu受体阳性变构的调节剂（Positive allosteric modulator of group I mGlu receptors）。

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  • Ro 67-7476 EI2370

    Ro 67-7476是mGlu1的阳性变构的调节剂（positive allosteric modulator）。

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