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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • R 268712 EI2299

    R 268712是TGF-βRI的活性选择性抑制剂。

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  • R 568 hydrochloride EI2300

    R 568 hydrochloride是人 calcium-sensing 受体的阳性变构的调节剂（positive allosteric modulator）。

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  • R 59-022 EI2301

    R 59-022是Diacylglycerol 激酶抑制剂， 同时可以增强protein kinase C ( PKC ) 的活性。

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  • QNZ 46 EI2284

    QNZ 46是NR2C/NR2D-选择性 NMDA 受体非竞争性拮抗剂。

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  • QO 58 EI2285

    QO 58是KV7通道开启剂（channel opener）。

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