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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Ro 67-4853 EI2369

    Ro 67-4853是group I mGlu受体阳性变构的调节剂（Positive allosteric modulator of group I mGlu receptors）。

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  • Ro 67-7476 EI2370

    Ro 67-7476是mGlu1的阳性变构的调节剂（positive allosteric modulator）。

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  • Ro 90-7501 EI2372

    Ro 90-7501是Aβ42 fibril formation的抑制剂。

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  • Ro 20-1724 EI2358

    Ro 20-1724是PDE4 抑制剂。

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  • Ro 25-6981 maleate EI2359

    Ro 25-6981 maleate是NR2B选择性 NMDA 拮抗剂。

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