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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • Spaglumic acid EI2591

    Spaglumic acid是选择性mGlu3激动剂。

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  • SIS3 EI2559

    SIS3是选择性 Smad3 抑制剂， 抑制 TGF-βR1信号通路。

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  • Sivelestat sodium salt EI2561

    Sivelestat sodium salt是选择性 leukocyte elastase 抑制剂。

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  • SKA 31 EI2563

    SKA 31是KCa3.1，KCa2 通道的激动剂。

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  • SIB 1893 EI2548

    SIB 1893是mGlu5的拮抗剂，mGlu4的阳性变构的调节剂（positive allosteric modulator）。

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