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Signal Pathway


In some cases, receptor activation caused by ligand binding to a receptor is directly coupled to the cell's response to the ligand. For example, the neurotransmitter GABA can activate a cell surface receptor that is part of an ion channel. GABA binding to a GABAA receptor on a neuron opens a chloride-selective ion channel that is part of the receptor. GABAA receptor activation allows negatively charged chloride ions to move into the neuron, which inhibits the ability of the neuron to produce action potentials.

  • TCS 21311 EI2727

    TCS 21311是活性的 JAK3 抑制剂。 也抑制 GSK-3β和PKC。

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  • TCS 3035 EI2730

    TCS 3035是GPR35的激动剂。

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  • TC-N 22A EI2717

    TC-N 22A是活性选择性mGlu4的阳性变构的调节剂（positive allosteric modulator）。

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  • TCN 237 dihydrochloride EI2718

    TCN 237 dihydrochloride是高活性选择性的NR2B拮抗剂。

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  • TCN 238 EI2719

    TCN 238是mGlu4阳性变构的调节剂（positive allosteric modulator）。

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